Hormone Replacement Therapy (HRT) is generally not considered painful, and most patients report minimal to no discomfort during their treatments. Pellet therapy, a popular option for long-lasting, steady hormone release, involves a small pellet being inserted under the skin. Afterward, you may experience mild soreness or bruising at the insertion site for a day or two, but this typically fades quickly. For injections or topical treatments, discomfort is even more minimal, usually just a quick pinch or none at all.

How Many Appointments Will I Need?

Your appointment schedule depends on your personalized treatment plan and how your body responds to therapy. Initially, you’ll meet with our team for a consultation and thorough lab testing to assess your hormone levels and discuss your symptoms. Once your treatment begins, follow-up visits are typically scheduled every few months to monitor your progress and adjust your dosage if necessary. Patients receiving pellet therapy often return every 3–6 months for re-insertion, while those on injections or creams may have more frequent check-ins.

How Long Until I See the Results?

Everyone’s experience with HRT is a little different, but many patients begin noticing improvements within the first few weeks. Energy levels, mood, sleep quality, and mental clarity are often the first areas where people feel a positive shift. Physical changes—like improved muscle tone, reduced body fat, or better skin texture—can take a little longer to show, especially with pellet therapy, which gradually releases hormones over time. Full results typically develop over the course of 3 to 6 months.

Can I Combine HRT with Other Procedures?

Yes, and combining HRT with other treatments can actually enhance your results. Lux Skin Lasers offers a wide range of aesthetic and wellness services that pair beautifully with hormone therapy. For example, many patients choose to complement HRT with facial rejuvenation , laser treatments , or body contouring to align their outward appearance with how great they feel internally. Since HRT can restore vitality, improve skin elasticity, and boost overall wellness, it often amplifies the effects of cosmetic procedures.

What Are the Risks Associated with HRT?

While HRT is safe for most patients, especially when administered under expert care, it does carry some risks like any medical treatment. Possible side effects may include acne, bloating, breast tenderness, mood swings, or minor fluid retention. In rarer cases, hormone therapy may affect blood pressure or increase the risk of certain health conditions, particularly if underlying issues go undetected. That’s why we begin with comprehensive lab work and closely monitor your hormone levels throughout your treatment.

Transdermal Hormone Replacement Therapy (HRT)

Transdermal Hormone Replacement Therapy (HRT), which delivers hormones through the skin via patches, gels, or creams, offers several advantages over oral HRT: Bypasses the Liver – Unlike oral HRT, transdermal delivery avoids the first-pass metabolism in the liver, reducing strain and lowering the risk of liver-related complications. Lower Risk of Blood Clots—Studies suggest that oral HRT has a reduced risk of deep vein thrombosis (DVT) and other clotting issues. Steady Hormone Levels – Provides a more consistent hormone release, avoiding spikes and crashes common with oral forms. Customizable Dosing – Gels and creams allow for flexible dosing adjustments based on individual needs.

King Of Prussia & Bryn Mawr

HRT

Introduction

Introduction to HRT

Hormones affect nearly every aspect of health, from energy levels and mental clarity to skin, mood, sleep, and even body composition. They make up who we are, and when they’re out of sorts, it can be extremely uncomfortable and difficult to deal with, often needing professional intervention.

At Lux Skin Lasers, we’re proud to offer personalized hormone replacement therapy (HRT) for individuals looking to restore balance and feel like themselves again. If you’re navigating symptoms of perimenopause, menopause, or andropause (male hormone decline), our approach is grounded in decades of experience and a commitment to your long-term wellness.

Under the guidance of Dr. Joseph Castelli, who brings over 30 years of experience in hormone therapy in the greater Philadelphia area and Margate, NJ, we take a thoughtful, evidence-based approach to every treatment plan. If you’ve been feeling “off” and suspect hormones may be the cause, we’re here to help you reconnect with your body and reclaim your quality of life safely, naturally, and with expert care.

Lux Skin Lasers by Dr. John Lee is conveniently located in King of Prussia, just 15 miles northwest of Philadelphia, and an easy drive from Malvern, Collegeville, Paoli, Berwyn, and Devon.

What is HRT?

Hormone Replacement Therapy (HRT) is a medical treatment that restores hormonal balance in the body. This often means replacing declining estrogen, progesterone, and/or testosterone levels to help relieve symptoms tied to age-related hormonal shifts. Treatment may include bioidentical hormones structurally identical to the hormones your body produces for a more natural response and fewer side effects. HRT can be delivered in various forms, such as creams, pellets, injections, or patches, and your doctor will help determine the best method for you.

A middle-aged woman with shoulder-length brown hair looks at herself in a round gold-framed mirror. She wears a loose white shirt, a gold pendant necklace, and a gold ring. The soft, warm lighting highlights her serious expression, with a muted background and a second person's hand subtly visible. - Minoxidil in King of Russia, PA

What Are the Benefits of a HRT?

Hormone Replacement Therapy (HRT) offers several benefits for both men and women by addressing hormonal imbalances that occur due to aging or medical conditions.

Benefits of HRT for Men (Testosterone Replacement Therapy – TRT):

Increased Energy & Vitality – Helps combat fatigue and improves overall well-being.
Enhanced Muscle Mass & Strength – Supports muscle growth and prevents muscle loss.
Improved Bone Density – Reduces the risk of osteoporosis and fractures.
Better Mood & Cognitive Function – Helps with depression, anxiety, and mental clarity.
Higher Libido & Sexual Function – Restores sexual drive and performance.
Metabolic Support – Can aid in fat loss and improve insulin sensitivity.

Benefits of HRT for Women (Estrogen and/or Progesterone Therapy):

Relief from Menopause Symptoms – Reduces hot flashes, night sweats, and mood swings.
Improved Bone Health – Lowers the risk of osteoporosis and fractures.
Enhanced Heart Health – May help maintain cholesterol levels and reduce heart disease risk.
Better Vaginal & Urinary Health – Prevents vaginal dryness and reduces urinary issues.
Improved Skin & Hair Quality – Helps maintain skin elasticity and reduces hair thinning.
Cognitive & Mood Benefits – May support memory and reduce depression or anxiety in some women.

Who Are the Best Candidates for HRT?

The best candidates for hormone replacement therapy are typically individuals who are experiencing symptoms of hormonal imbalance, such as fatigue, brain fog, low libido, weight gain, mood swings, sleep disturbances, or changes in skin tone and elasticity. This often includes women in perimenopause or menopause and men experiencing andropause (low testosterone). Ideal candidates are generally in good health and are ready to take an active role in improving their wellness. If you’re not feeling like yourself and suspect your hormones could be the cause, a consultation with our experienced HRT team around Philadelphia can help determine whether this treatment is right for you.

What’s the First Step?

Starting HRT at Lux Skin Lasers in King of Prussia (the greater Philadelphia area) and at our Margate, New Jersey location is a thoughtful and personalized process. Your first step will be to schedule a comprehensive consultation with our experienced medical team. During this visit, we’ll take a deep dive into your medical history, lifestyle, symptoms, and wellness goals, followed by bloodwork to evaluate your current hormone levels. Once we have a clear picture of what your body needs, we’ll design a customized treatment plan that may include bioidentical hormone therapy through methods like pellets, injections, or topicals. You’ll also receive education on what to expect, how to track your progress, and how to stay supported throughout your journey.

What to Expect on the Day of HRT Treatment

Depending on the delivery method selected for your HRT, your treatment day will be quick and relatively simple. For pellet therapy, which is one of the most popular and low-maintenance options, tiny hormone pellets are inserted just beneath the skin during a short in-office procedure. It only takes about 15–30 minutes and involves little to no downtime. If you’re receiving injections or topical therapy, those can also be administered with minimal fuss right here at our Philadelphia-area office. Regardless of the method, your treatment will be discreet, comfortable, and performed under expert medical care. Most patients are able to return to normal activities the same day.

HRT Recovery

Recovery after HRT is generally very easy. If you’ve chosen pellet therapy, you may experience some mild soreness or bruising at the insertion site for a day or two, but this fades quickly. There are no major restrictions, though we may recommend avoiding intense lower-body workouts for a few days post-insertion.

Beyond that, the real “recovery” lies in how your body adjusts to hormone optimization over the coming weeks. You may notice gradual improvements in energy, mood, sleep, and other symptoms within 1–2 weeks, with full effects typically felt after a month or two. We’ll monitor your progress throughout your treatment and make any adjustments needed to keep you feeling your best.

How Much Does HRT Cost in King of Prussia, PA and Margate?

The cost of HRT in Philadelphia and Margate can vary depending on several factors, including the type of hormones used (such as bioidentical pellets or injections), the length of your treatment plan, and the level of lab testing and follow-up needed. On average, patients can expect to invest anywhere from $250 to $500 per month for ongoing HRT. Keep in mind, this isn’t a one-size-fits-all treatment. Instead, it’s a tailored solution designed to support your overall wellness and quality of life. We’ll provide a detailed breakdown of your expected costs during your consultation, including all labs, appointments, and medication.

Why Choose Lux Skin Lasers?

With over 30 years of experience in hormone therapy, Dr. Joseph Castelli leads the HRT program at Lux Skin Lasers with an unmatched level of expertise and compassion. We’re proud to serve patients across Bryn Mawr, King of Prussia, Margate and greater Philadelphia with a science-backed, individualized approach to aging and hormone health. Our mission is simple: to help you feel like yourself again, with more energy, better sleep, mental clarity, and a renewed sense of vitality. From the moment you walk in, you’ll experience our warm, boutique atmosphere and a team dedicated to your long-term wellness.

HRT FAQ’S

Hormone Replacement Therapy (HRT) is generally not considered painful, and most patients report minimal to no discomfort during their treatments. Pellet therapy, a popular option for long-lasting, steady hormone release, involves a small pellet being inserted under the skin. Afterward, you may experience mild soreness or bruising at the insertion site for a day or two, but this typically fades quickly. For injections or topical treatments, discomfort is even more minimal, usually just a quick pinch or none at all.
Your appointment schedule depends on your personalized treatment plan and how your body responds to therapy. Initially, you’ll meet with our team for a consultation and thorough lab testing to assess your hormone levels and discuss your symptoms. Once your treatment begins, follow-up visits are typically scheduled every few months to monitor your progress and adjust your dosage if necessary. Patients receiving pellet therapy often return every 3–6 months for re-insertion, while those on injections or creams may have more frequent check-ins.
Everyone’s experience with HRT is a little different, but many patients begin noticing improvements within the first few weeks. Energy levels, mood, sleep quality, and mental clarity are often the first areas where people feel a positive shift. Physical changes—like improved muscle tone, reduced body fat, or better skin texture—can take a little longer to show, especially with pellet therapy, which gradually releases hormones over time. Full results typically develop over the course of 3 to 6 months.
Yes, and combining HRT with other treatments can actually enhance your results. Lux Skin Lasers offers a wide range of aesthetic and wellness services that pair beautifully with hormone therapy. For example, many patients choose to complement HRT with facial rejuvenation, laser treatments, or body contouring to align their outward appearance with how great they feel internally. Since HRT can restore vitality, improve skin elasticity, and boost overall wellness, it often amplifies the effects of cosmetic procedures.
While HRT is safe for most patients, especially when administered under expert care, it does carry some risks like any medical treatment. Possible side effects may include acne, bloating, breast tenderness, mood swings, or minor fluid retention. In rarer cases, hormone therapy may affect blood pressure or increase the risk of certain health conditions, particularly if underlying issues go undetected. That’s why we begin with comprehensive lab work and closely monitor your hormone levels throughout your treatment.
Transdermal Hormone Replacement Therapy (HRT), which delivers hormones through the skin via patches, gels, or creams, offers several advantages over oral HRT:
1. Bypasses the Liver – Unlike oral HRT, transdermal delivery avoids the first-pass metabolism in the liver, reducing strain and lowering the risk of liver-related complications.
2. Lower Risk of Blood Clots—Studies suggest that oral HRT has a reduced risk of deep vein thrombosis (DVT) and other clotting issues.
3. Steady Hormone Levels – Provides a more consistent hormone release, avoiding spikes and crashes common with oral forms.
4. Customizable Dosing – Gels and creams allow for flexible dosing adjustments based on individual needs.
Testosterone Replacement Therapy (TRT) can be beneficial for men with low testosterone, but it also carries potential complications, including:
- Cardiovascular Risks: Increased risk of high blood pressure, heart attacks, and strokes in some individuals.
- Blood-Related Issues: TRT can raise red blood cell levels (polycythemia), increasing the risk of blood clots.
- Hormonal Imbalances: Gynecomastia (breast enlargement): Excess testosterone can be converted into estrogen.
- Testicular shrinkage and infertility: TRT suppresses natural testosterone production, leading to reduced sperm count.
- Skin and Hair Changes: Acne, oily skin, and potential hair loss in men predisposed to male pattern baldness.
- Mood and Behavioral Changes: Increased aggression or mood swings in some individuals.
- Sleep Disturbances: Worsening of sleep apnea in those prone to the condition.
- Prostate Health Concerns: May stimulate growth of benign prostatic hyperplasia (BPH) or, in rare cases, influence prostate cancer progression (though research is inconclusive).
Because of these risks, TRT should be carefully monitored by a healthcare provider with regular blood tests and follow-ups.

5.0 – 301 Reviews

Lux Jawline Lyft

I recently had a LUX Jawline lyft with Dr. Lee, and I am beyond thrilled with the results! From my initial consultation, Dr. Lee and his team went above and beyond to make sure I felt comfortable.

Testimonials Aubrey L.
Great Listener

I have been seeing Dr Castelli at Lux for some time. He is a great listener and the final result of any treatments always exceeds my expectations! He is honest and gentle and cares about his patients. I highly recommend him for injections and/or weight loss!

Reviews Nikki K
Gave me hope!

Dr Castelli gave me hope! It’s so encouraging to know there are things he can do to take away some of the signs of aging & I felt so comfortable with him. He was professional yet still friendly & personable, as were his assistants. He explained everything clearly & made suggestions that fit my needs. I am so excited to move forward with all of my skin care concerns.

Schedule a consultation

If you’re ready to take the next step toward hormonal balance and better living, we’re here to help. Scheduling your consultation at Lux Skin Lasers is quick and easy—just give us a call at 610-789-6701 or fill out our online form, and we’ll guide you from there.

Schedule Now

HRT